Sathgen Therapeutics

Transforming cancer treatment with novel targets

Sathgen Therapeutics – developing innovative oncology therapies for difficult-to-treat cancers

Welcome to Sathgen Therapeutics

We are a clinical-stage biotech company committed to discovering and developing innovative treatments for cancer patients to improve quality of life. Our lead drug candidate is in phase I clinical trials in patients with advanced solid tumors, as well as in healthy individuals – to evaluate safety, tolerability and pharmacokinetics of the drug. We are focused on developing pioneering therapies to fight cancer. As a division of Godavari Biorefineries Limited, we are backed by a strong financial support from a conglomerate that produces foods, biofuels, chemicals, pharmaceutical intermediates, power, compost, biomaterials, and related products. Our state-of-the-art R&D facility and expertise in anti-cancer drug design & development make us a strong player in the fight against cancer.

Learn More

Our Solution

At Sathgen Therapeutics, we use an integrated approach to study and target the difficult-to-treat cancers. Hence, our solution involves examining the disease as a complex system as opposed to a one-gene-one-disease remedy. In addition to targeting cancers, our drug can also treat viral infections such as COVID-19.

Explore More

Strong Financial and Technical Support

Sathgen Therapeutics has strong financial and technical support to help achieve its goals. We are backed by Godavari Biorefineries Limited (GBL), and linked to the Somaiya Group, which is actively involved in healthcare and education. Our CRO partner, Clinexel, provides expertise in early-stage clinical development and capabilities for global clinical development. With the support of our partners, we are confident that we can bring new and innovative therapies to patients in need.

Visit GBL

Highlights of recent studies

Clinical studies:

Initiation of phase I trials of MSP008-22 in patients with advanced solid tumors in February 2023.

Completion of the dosing of the first cohort of patients in the phase I clinical trial of MSP008-22 in June 2023.

Initiation of phase I trials of MSP008-22 in healthy individuals in April 2023.

Completion of the dosing of the first two cohorts of healthy volunteers in the phase I clinical trial of MSP008-22 in July 2023.

Preclinical Studies (Oncology):

Xenograft studies with triple negative breast cancer cells show tumor growth inhibition upon single arm MSP008-22 or in combination with standard-of-care chemotherapy, Carboplatin.

MSP008-22 improves the efficacy and lowers toxicity of another standard-of-care chemotherapy, Cisplatin, as shown by decreased IC50.

MSP008-22 shows excellent safety profile in pre-clinical models including induced human blood lymphocytes.

MSP008-22 also shows anti-stem cell and anti-metastatic efficacy in breast and prostate cancer models, in vitro.

Preclinical Studies (Anti-Viral):

Treatment with MSP008-22, both post-infection or prophylactic, reduces the SARS-CoV-2 viral load, and COVID-19-asscoiated Pneumonitis, alveolar injury, and inflammation score.

MSP008-22 inhibits viral replication to the same extent as the anti-viral, Remdesivir.

MSP008-22 shows anti-SARS-CoV-2 potential as observed in cytopathic assays, comparable to Remdesivir.

Sathgen Therapeutics is a clinical-stage biotech company working on bringing the first-in-class and best-in-class drugs ensuring novel treatments for difficult-to-treat cancers and potentially viral infections.